In addition to the factors Gecko and Thomas mentioned, there is also the factor of price.
How much are you willing to spend to get the flow you want?
For example, in my own 125 gal reef I use a pair of Tunze Stream pumps on a Tunze multicontroller. The flow using this system is one of the best random flow patterns I can get, since the multicontroller is set up by the user. Many different flows can be generated. The downside is that two stream pumps and the multicontroller will cost you about $900 today.
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